Liverpool forward Mohamed Salah will miss the crunch clash against Manchester United due to injury, but manager Arne Slot confirms his return before season end.
Arsenal cleared arguably the most dangerous remaining obstacle in their path to the Premier League title by the skin of their teeth as Leandro Trossard's late goal secured a dramatic 1-0 win at West Ham United to restore their five-point lead on Sunday.
Liverpool secured a dominant win over West Ham, while other Premier League matches saw Brentford edge Burnley in a seven-goal thriller and Everton secure a late victory against Newcastle.
Champions Chelsea begin title defence at home to Swansea City, while runners-up Manchester City kick-off at West Bromwich Albion
The much-anticipated clash between Liverpool and ManchesterCity at Anfield on Saturday looks like a knockout to determine who can challenge Chelsea for the Premier League title.
Liverpool and Manchester United's globe-trotting squads must shake off the effects of international duty for one of English football's most eagerly-anticipated clashes on Saturday.
English Premier League leaders Liverpool will need to maintain their excellent recent record against Everton in Sunday's Merseyside derby if they are to hold their advantage over second-placed Manchester City.
Manchester City can pile the pressure on Premier League leaders Chelsea for the first time this season.
Manchester United manager Louis van Gaal will delve into the depths of his squad for the visit to Arsenal in the Premier League on Saturday, as an injury crisis engulfs Old Trafford.
Rewind five years and Liverpool hosted Chelsea with three games remaining, knowing victory would have left them six points clear and a first league title since 1990 almost secure.
Champions Chelsea have not enjoyed the best of starts at home this season and face their biggest test yet on Saturday with the visit of free-scoring leaders Manchester City.
Saturday's clash between Manchester United and Tottenham Hotspur at Old Trafford is already shaping up as an early-season eliminator to challenge runaway leaders Manchester City for the Premier League title.
Following is a match by match look at the English Premier League's weekend fixtures
Champions Leicester City will begin their Premier League title defence with a trip to newly promoted Hull City on August 13, according to the 2016-17 fixtures released on Wednesday.
Manchester City host Tottenham Hotspur on Saturday on the back of a record 15 successive English Premier League wins, and on the basis of their visitors' recent away form, a 16th victory appears to be the likely outcome.
Liverpool target Chelsea after midweek tinkering, while third-placed Manchester City, whose hopes of qualifying for the Champions League knockout stage were dealt a severe blow in a humiliating 2-1 home defeat by CSKA Moscow on Wednesday, travel south to face struggling Queens Park Rangers.
IMAGES from the English Premier League matches played on Saturday.
Preview and timings of the Premier League matches this weekend
Images from the English Premier League matches played at Old Trafford on Saturday
The destination of the Premier League trophy will not be decided when current champions Chelsea meet their immediate predecessors Manchester City.
The Premier League's leading goalscorers will be on show at when surprise leaders Leicester City bid to move further ahead at the top with victory against Everton at Goodison Park on Saturday.
In case they needed it, the short trip to Crystal Palace will re-focus Chelsea's globe-trotting players on matters at home as the Premier League slips back into gear this weekend after the second international break of the season.
Rediff.com brings a preview of the main matches coming up this weekend in the English Premier League.
Following is a match by match look at the English Premier League's weekend fixtures:
Arsenal and Manchester City meet at The Emirates on Saturday when both teams will seek to roar into life after making spluttering starts to their Premier League campaigns.
Following is a match by match look at the English Premier League's weekend fixtures:
The omens are good for a Chelsea side heading into Christmas top of the Premier League tree but manager Jose Mourinho does not want to give title rivals Manchester City any reason to cheer over the festive season. Check out the big games on Boxing Day.
News of all that's transpired on and off the football field.
News of all that tranpired on and off the football field.
